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Leptomeningeal carcinomatosis associated with oesophageal adenocarcinoma : two case reports and review of the literature

Journal Volume 69 - 2006
Issue Fasc.4 - Case reports
Author(s) Karel Goddeeris, Chris Verslype, Guido Wilms, Eric Van Cutsem
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(1) Department of Internal Medicine ; (2) Department of Internal Medicine Digestive Oncology Unit ; (3) Department of Radiology ; (4) Department of Internal Medicine Digestive Oncology Unit, University Hospital Gasthuisberg, Leuven, Belgium.

Leptomeningeal carcinomatosis (LC) is a rare complication of solid tumours. We report two cases of leptomeningeal carcino- matosis in patients with oesophageal adenocarcinoma. Diagnosis of LC can be overlooked without a high index of suspicion. Multifocality of symptoms and signs is the hallmark of LC. The combination of cerebrospinal fluid cytology and magnetic reso- nance imaging has a high diagnostic accuracy. The prognosis remains poor and therefore all therapies are still palliative. (Acta gastroenterol. belg., 2006, 69, 377-380).

© Acta Gastro-Enterologica Belgica.